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Chang Huang     University Educator/Researcher 
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Chang Huang published an article in August 2018.
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(1970 - 2018)
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Article 1 Read 0 Citations Seeing Surface Water From Space Chang Huang Published: 01 August 2018
doi: 10.1029/2018eo103123
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Satellite-based optical sensors can detect, measure and monitor changes in lakes, reservoirs, rivers and wetlands, providing useful data with multiple applications for science and society.
Article 0 Reads 3 Citations Detecting, Extracting, and Monitoring Surface Water From Space Using Optical Sensors: A Review Chang Huang, Yun Chen, Shiqiang Zhang, Jianping Wu Published: 06 June 2018
Reviews of Geophysics, doi: 10.1029/2018rg000598
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Observation of surface water is a functional requirement for studying ecological and hydrological processes. Recent advances in satellite‐based optical remote sensors have promoted the field of sensing surface water to a new era. This paper reviews the current status of detecting, extracting and monitoring surface water using optical remote sensing, especially progress in the last decade. It also discusses the current status and challenges in this field, including spatio‐temporal scale issues, integration with in situ hydrological data and elevation data, obscuration caused by clouds and vegetation, and the growing need to map surface water at a global scale. Historically, sensors have exhibited a contradiction in resolutions. Techniques including pixel unmixing and reconstruction, and spatio‐temporal fusion have been developed to alleviate this contradiction. Spatio‐temporal dynamics of surface water have been modeled by combining remote sensing data with in situ river flow. Recent studies have also demonstrated that the river discharge can be estimated using only optical remote sensing imagery, providing valuable information for hydrological studies in ungauged areas. Another historical issue for optical sensors has been obscuration by clouds and vegetation. An effective approach of reducing this limitation is to combine with Synthetic Aperture Radar (SAR) data. Digital Elevation Model (DEM) data have also been employed to eliminate cloud/terrain shadows. The development of big data and cloud computation techniques make the increasing demand of monitoring global water dynamics at high resolutions easier to achieve. An integrated use of multi‐source data is the future direction for improved global and regional water monitoring.
Article 0 Reads 0 Citations Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP + -induced decline of mitochondrial membr... Jiahong Zhong, Hui Yu, Chang Huang, Qiuping Zhong, Yaping Ch... Published: 01 June 2018
Redox Biology, doi: 10.1016/j.redox.2018.02.008
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Phosphodiesterase 4 (PDE4) is a promising target for the treatment of Parkinson's disease (PD). However, the underlying mechanism has not yet been well elucidated. Additionally, most of current PDE4 inhibitors produce severe nausea and vomiting response in patients, which limit their clinical application. FCPR16 is a novel PDE4 inhibitor with little emetic potential. In the present study, the neuroprotective effect and underlying mechanism of FCPR16 against cellular apoptosis induced by 1-methyl-4-phenylpyridinium (MPP+) were examined in SH-SY5Y cells. FCPR16 (12.5–50 μM) dose-dependently reduced MPP+-induced loss of cell viability, accompanied by reductions in nuclear condensation and lactate dehydrogenase release. The level of cleaved caspase 3 and the ratio of Bax/Bcl-2 were also decreased after treatment with FCPR16 in MPP+-treated cells. Furthermore, FCPR16 (25 μM) significantly suppressed the accumulation of reactive oxygen species (ROS), prevented the decline of mitochondrial membrane potential (Δψm) and attenuated the expression of malonaldehyde level. Further studies disclosed that FCPR16 enhanced the levels of cAMP and the exchange protein directly activated by cAMP (Epac) in SH-SY5Y cells. Western blotting analysis revealed that FCPR16 increased the phosphorylation of cAMP response element-binding protein (CREB) and protein kinase B (Akt) down-regulated by MPP+ in SH-SY5Y cells. Moreover, the inhibitory effects of FCPR16 on the production of ROS and Δψm loss could be blocked by PKA inhibitor H-89 and Akt inhibitor KRX-0401. Collectively, these results suggest that FCPR16 attenuates MPP+-induced dopaminergic degeneration via lowering ROS and preventing the loss of Δψm in SH-SY5Y cells. Mechanistically, cAMP/PKA/CREB and Epac/Akt signaling pathways are involved in these processes. Our findings indicate that FCPR16 is a promising pre-clinical candidate for the treatment of PD and possibly other oxidative stress-related neuronal diseases.
Article 3 Reads 1 Citation Exploring spatiotemporal patterns of electric power consumption in countries along the Belt and Road Kaifang Shi, Bailang Yu, Chang Huang, Jianping Wu, Xiufeng S... Published: 01 May 2018
Energy, doi: 10.1016/
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Article 4 Reads 1 Citation JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process Ling Wang, Zongliang Jiang, Delun Huang, Jingyue Duan, Chang... Published: 06 March 2018
BMC Genomics, doi: 10.1186/s12864-018-4507-2
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The generation of induced pluripotent stem cells (iPSCs) has underdefined mechanisms. In addition, leukemia inhibitory factor (LIF) activated Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway is the master regulator for naïve-state pluripotency achievement and maintenance. However, the regulatory process to attain naïve pluripotent iPSCs is not well understood. We performed transcriptome analysis to dissect the genomic expression during mouse iPSC induction, with or without blocking the JAK/STAT3 activity. We describe JAK/STAT3 signaling-specific biological events such as gametogenesis, meiotic/mitotic cell cycle, and DNA repair, and JAK/STAT3-dependent expression of key transcription factors such as the naïve pluripotency-specific genes, developmental pluripotency associated (Dppa) family, along with histone modifiers and non-coding RNAs in reprogramming. We discover that JAK/STAT3 activity does not affect early phase mesenchymal to epithelial transition (MET) but is necessary for proper imprinting of the Dlk1-Dio3 region, an essential event for pluripotency achievement at late-reprogramming stage. This correlates with the JAK/STAT3-dependent stimulation of Dppa3 and Polycomb repressive complex 2 (PRC2) genes. We further demonstrate that JAK/STAT3 activity is essential for DNA demethylation of pluripotent loci including Oct4, Nanog, and the Dlk1-Dio3 regions. These findings correlate well with the previously identified STAT3 direct targets. We further propose a model of pluripotency achievement regulated by JAK/STAT3 signaling during the reprogramming process. Our study illustrates novel insights for JAK/STAT3 promoted pluripotency establishment, which are valuable for further improving the naïve-pluripotent iPSC generation across different species including humans.
Article 1 Read 0 Citations Quick approximate elastoplastic solutions of wellbore stability problems based on numerical simulation and statistical a... Chang Huang, Babak Akbari, Shengli Chen Published: 01 March 2018
Journal of Natural Gas Science and Engineering, doi: 10.1016/j.jngse.2018.01.005
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