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Giovanni Cenci  - - - 
Top co-authors See all
Silvia Meniconi

70 shared publications

Department of Civil and Environmental Engineering, University of Perugia, 06125 Perugia

Loredana Capobianco

47 shared publications

Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy

Vincenza Dolce

47 shared publications

Department of Pharmacy, Health, and Nutritional Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

Ermanno Federici

31 shared publications

Laboratory of Microbiology, Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy

Aldo Corsetti

20 shared publications

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy

Publication Record
Distribution of Articles published per year 
(1974 - 2017)
Total number of journals
published in
Publications See all
Article 3 Reads 1 Citation Food-Associated Lactobacillus plantarum and Yeasts Inhibit the Genotoxic Effect of 4-Nitroquinoline-1-Oxide Roberta Prete, Ermanno Federici, Aurora Ciarrocchi, Giovanni... Published: 28 November 2017
doi: 10.3389/fmicb.2017.02349
DOI See at publisher website ABS Show/hide abstract
Lactic acid bacteria and yeasts, representing the prevailing microbiota associated with different foods generally consumed without any cooking, were identified and characterized in vitro for some functional properties, such as acid-bile tolerance and antigenotoxic activity. In particular, 22 Lactobacillus plantarum strains and 14 yeasts were studied. The gastro-intestinal tract tolerance of all the strains was determined by exposing washed cell suspensions at 37°C to a simulated gastric juice (pH 2.0), containing pepsin (0.3% w/v) and to a simulated small intestinal juice (pH 8.0), containing pancreatin (1 mg mL-1) and bile extract (0.5%), thus monitoring changes in total viable count. In general, following a strain-dependent behavior, all the tested strains persisted alive after combined acid-bile challenge. Moreover, many strains showed high in vitro inhibitory activity against a model genotoxin, 4-nitroquinoline-1-oxide (4-NQO), as determined by the short-term method, SOS-Chromotest. Interestingly, the supernatants from bacteria- or yeasts-genotoxin co-incubations exhibited a suppression on SOS-induction produced by 4-NQO on the tester strain Escherichia coli PQ37 (sfiA::lacZ) exceeding, in general, the value of 75%. The results highlight that food associated microorganisms may reach the gut in viable form and prevent genotoxin DNA damage in situ. Our experiments can contribute to elucidate the functional role of food-associated microorganisms general recognized as safe ingested with foods as a part of the diet.
Article 2 Reads 0 Citations Legionella Survey in the Plumbing System of a Sparse Academic Campus: A Case Study at the University of Perugia Ermanno Federici, Silvia Meniconi, Elisa Ceci, Elisa Mazzett... Published: 01 September 2017
Water, doi: 10.3390/w9090662
DOI See at publisher website ABS Show/hide abstract
We have monitored the presence of bacteria belonging to the genus Legionella in the plumbing of buildings at the University of Perugia (Italy). More than 300 water samples were collected from 156 control-point taps in 41 buildings comprised in the eight campuses of the University. Legionella was absent in most samples, while it was found in only 12 buildings (29% of the total). Molecular analysis indicated the presence of L. pneumophila (serogroups 1, 8 and 6–10), L. taurinensis and L. anisa. In only three cases contamination levels were above the limit at which remedial actions are required, according to international guidelines. In two buildings, where the water temperature could be raised and maintained above 60 °C, thermal disinfection was effective in eradicating Legionella. Conversely, in buildings where contaminations were caused by heat exchangers that produced hot water at a maximum temperature of 50 °C, a chemical disinfection with silver hydrogen peroxide was carried out but was effective only in the short term. In this case study, Legionella contaminations and remediation effectiveness strongly depended on the network and heating-system characteristics, indicating how a multidisciplinary approach that integrates microbiological analysis with hydraulic surveys is necessary for an effective definition of Legionella prevention and control strategies.
Article 1 Read 0 Citations Effects of reduced natural background radiation on Drosophila melanogaster growth and development as revealed by the FLY... Patrizia Morciano, Roberto Iorio, Daniela Iovino, Francesca ... Published: 05 June 2017
Journal of Cellular Physiology, doi: 10.1002/jcp.25889
DOI See at publisher website PubMed View at PubMed
Article 3 Reads 1 Citation Bacterial Composition, Genotoxicity, and Cytotoxicity of Fecal Samples from Individuals Consuming Omnivorous or Vegetari... Ermanno Federici, Roberta Prete, Camilla Lazzi, Nicoletta Pe... Published: 28 February 2017
doi: 10.3389/fmicb.2017.00300
DOI See at publisher website ABS Show/hide abstract
This study analyzes the composition of viable fecal bacteria and gut toxicology biomarkers of 29 healthy volunteers, who followed omnivorous, lacto-ovo-vegetarian, or vegan diets. In particular, the research was focused on the prevalence of some representative viable bacteria from the four dominant phyla (Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria) commonly present in human feces, in order to evaluate the relationship between microorganisms selected by the habitual dietary patterns and the potential risk due to fecal water (FW) genotoxicity and cytotoxicity, considered as biomarkers for cancer risk and protective food activity. The relative differences of viable bacteria among dietary groups were generally not statistically significant. However, compared to omnivores, lacto-ovo-vegetarians showed low levels of total anaerobes. Otherwise, vegans showed total anaerobes counts similar to those of omnivores, but with lower number of bifidobacteria and the highest levels of bacteria from the Bacteroides–Prevotella genera. FW genotoxicity of lacto-ovo-vegetarians resulted significantly lower either in relation to that of omnivores and vegans. Lacto-ovo-vegetarians also showed the lowest levels of cytotoxicity, while the highest were found for vegans. These results highlighted that lacto-ovo-vegetarian diet was particularly effective in a favorable modulation of microbial activity, thus contributing to a significant reduction of the genotoxic and cytotoxic risk in the gut.
Conference 4 Reads 0 Citations Legionella monitoring in building’s water distribution systems: the case study of a sparse University campus Ermanno Federici, Silvia Meniconi, Bruno Brunone, Elisa Ceci... Published: 16 November 2016
The 1st International Electronic Conference on Water Sciences, doi: 10.3390/ecws-1-d001
DOI See at publisher website
Article 1 Read 5 Citations A role for Separase in telomere protection Francesca Cipressa, Patrizia Morciano, Giuseppe Bosso, Linda... Published: 18 January 2016
Nature Communications, doi: 10.1038/ncomms10405
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Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity and are assembled independently of the sequence. Fly telomeres are protected by the terminin complex that localizes and functions exclusively at telomeres and by non-terminin proteins that do not serve telomere-specific functions. We show that mutations in the Drosophila Separase encoding gene Sse lead not only to endoreduplication but also telomeric fusions (TFs), suggesting a role for Sse in telomere capping. We demonstrate that Separase binds terminin proteins and HP1, and that it is enriched at telomeres. Furthermore, we show that loss of Sse strongly reduces HP1 levels, and that HP1 overexpression in Sse mutants suppresses TFs, suggesting that TFs are caused by a HP1 diminution. Finally, we find that siRNA-induced depletion of ESPL1, the Sse human orthologue, causes telomere dysfunction and HP1 level reduction in primary fibroblasts, highlighting a conserved role of Separase in telomere protection.