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Cristina Suárez  - - - 
Top co-authors See all
José A. Salas

323 shared publications

Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, Oviedo, Spain

Joan Carles

235 shared publications

Vall d'Hebron Institute of Oncology; Vall d'Hebron University Hospital; Barcelona Spain

Stefano Indraccolo

119 shared publications

Istituto Oncologico Veneto IOV – IRCCS Padova Italy

Oriol Casanovas

98 shared publications

Tumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology – IDIBELL, Spain

Antonio Oliver

95 shared publications

Servicio de Microbiología and Unidad de Investigación, Hospital Son Espases, Instituto de Investigación Sanitaria de Baleares (IdISBa), Palma, Spain

Publication Record
Distribution of Articles published per year 
(1999 - 2018)
Total number of journals
published in
Publications See all
Article 2 Reads 0 Citations Understanding the drivers for Natura 2000 payments in forests: a Heckman selection analysis Zuzana Sarvašová, Sonia Quiroga, Cristina Suárez, Tamás Ali,... Published: 01 July 2018
Journal for Nature Conservation, doi: 10.1016/j.jnc.2018.07.003
DOI See at publisher website
Article 0 Reads 2 Citations Forest ownership changes in Europe: State of knowledge and conceptual foundations Gerhard Weiss, Anna Lawrence, Teppo Hujala, Gun Lidestav, Li... Published: 01 April 2018
Forest Policy and Economics, doi: 10.1016/j.forpol.2018.03.003
DOI See at publisher website
Conference 4 Reads 0 Citations Mapping coffee producers’ transition to cocoa as a response to global change: smallholders’ water needs and adaptation i... Sonia Quiroga, Cristina Suarez, Juan Diego Solís, Pablo Mart... Published: 22 November 2016
The 1st International Electronic Conference on Water Sciences, doi: 10.3390/ecws-1-e004
DOI See at publisher website
Article 4 Reads 0 Citations Impacto de la incorporación de la enfermera a una unidad de enfermedad inflamatoria intestinal Leticia Amo, Yago González-Lama, Cristina Suárez, Isabel Blá... Published: 01 May 2016
Gastroenterología y Hepatología, doi: 10.1016/j.gastrohep.2015.09.004
DOI See at publisher website PubMed View at PubMed
Article 4 Reads 20 Citations Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients Gabriela Jiménez-Valerio, Mar Martínez-Lozano, Nicklas Bassa... Published: 01 May 2016
Cell Reports, doi: 10.1016/j.celrep.2016.04.015
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
•Resistance to antiangiogenic therapy involves metabolic symbiosis patterning in RCC•mTOR pathway mediates this resistance and mTOR inhibition blocks metabolic symbiosis•In patients, antiangiogenics induce symbiotic patterning mostly in resistant tumors•mTOR pathway implication is also suggested in patients treated with antiangiogenics SummaryAntiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily serve to stabilize disease, and resistance eventually develops concomitant with progression. Here, we implicate metabolic symbiosis between tumor cells distal and proximal to remaining vessels as a mechanism of resistance to antiangiogenic therapies in patient-derived RCC orthoxenograft (PDX) models and in clinical samples. This metabolic patterning is regulated by the mTOR pathway, and its inhibition effectively blocks metabolic symbiosis in PDX models. Clinically, patients treated with antiangiogenics consistently present with histologic signatures of metabolic symbiosis that are exacerbated in resistant tumors. Furthermore, the mTOR pathway is also associated in clinical samples, and its inhibition eliminates symbiotic patterning in patient samples. Overall, these data support a mechanism of resistance to antiangiogenics involving metabolic compartmentalization of tumor cells that can be inhibited by mTOR-targeted drugs.
Article 3 Reads 0 Citations Impact of the incorporation of a nurse in an inflammatory bowel disease unit Leticia Amo, Yago González-Lama, Cristina Suárez, Isabel Blá... Published: 01 May 2016
Gastroenterología y Hepatología (English Edition), doi: 10.1016/j.gastre.2016.04.006
DOI See at publisher website